Skip to main page content Home OnlineFirst Current Issue Past Issues Subscriptions Alerts Feedback AACR Publications AACR Home Search GO Advanced Search User Name Password Sign In 
Transforming Properties of 8p11-12 Amplified Genes in Human Breast Cancer Zeng-Quan Yang1, Gang Liu1, Aliccia Bollig-Fischer1, Craig N. Giroux2, and Stephen P. Ethier1 Authors' Affiliations:1Breast Cancer Program and 2Systems and Computational Biology, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan Corresponding Author:Zeng-Quan Yang, Karmanos Cancer Institute, 4100 John R HWCRC 815, Detroit, MI 48201. Phone: 313-576-8339; Fax: 313-576-8029; E-mail: yangz{at}karmanos.org. Z.-Q. Yang and G. Liu contributed equally to this work. Abstract Amplification of the 8p11-12 region has been found in about 15% of human breast cancers and is associated with poor prognosis. Earlier, we used genomic analysis of copy number and gene expression to perform a detailed analysis of the 8p11-12 amplicon to identify candidate oncogenes in breast cancer. We identified 21 candidate genes and provided evidence that three genes, namely, LSM-1, TC-1, and BAG4, have transforming properties when overexpressed. In the present study, we systematically investigated the transforming properties of 13 newly identified 8p11-12 candidate oncogenes in vitro. WHSC1L1, DDHD2, and ERLIN2 were most potently transforming oncogenes based on the number of altered phenotypes expressed by the cells. WHSC1L1 contains a PWWP-domain that is a methyl-lysine recognition motif involved in histone code modification and epigenetic regulation of gene expression. Knockdown of WHSC1L1 in 8p11-12–amplified breast cancer cells resulted in profound loss of growth and survival of these cells. Further, we identified several WHSC1L1 target genes, one of which is iroquois homeobox 3 gene (IRX3), a member of the Iroquois homeobox transcription factor family. Cancer Res; 70(21); 8487–97. ©2010 AACR. Footnotes Note: Supplementary data for this article are available at Cancer Research Online (http://cancerres.aacrjournals.org/). Received March 22, 2010. Revision received August 27, 2010. Accepted August 27, 2010. ©2010 American Association for Cancer Research.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Facebook 
Reddit 
Technorati 
Twitter What's this? « Previous | Next Article »Table of Contents This Article Published OnlineFirst October 12, 2010; doi: 10.1158/0008-5472.CAN-10-1013 Cancer Res November 1, 2010 70; 8487 » Abstract Full Text Full Text (PDF) Supplementary Data All Versions of this Article: 0008-5472.CAN-10-1013v1 70/21/8487 most recent Classifications Molecular and Cellular Pathobiology Services Email this article to a colleague Alert me when this article is cited Alert me if a correction is posted Similar articles in this journal Similar articles in PubMed Download to citation manager 
Citing Articles Load citing article information Citing articles via Scopus Google Scholar Articles by Yang, Z. Articles by Ethier, S. P. PubMed PubMed citation Articles by Yang, Z. Articles by Ethier, S. P. Social Bookmarking CiteULike Complore Connotea Del.icio.us Digg Facebook Reddit Technorati Twitter What's this? :: AACR Publications Home :: 
Current Issue November 1, 2010, 70 (21) 
Alert me to new issues of Cancer Research About the Journal Information for Authors/ Submit Manuscript Editorial Board Information for Librarians Information for Readers/ Subscribers Information for Advertisers Permissions & Reprints E-mail Alerts & RSS Feeds [Free] 
Feedback Cancer Discovery Clinical Cancer Research Molecular Cancer Research Molecular Cancer Therapeutics Cancer Epidemiology Biomarkers & Prevention Cancer Prevention Research Cancer Prevention
Journals Portal Cancer Reviews Online Annual Meeting Education Book Meeting Abstracts Online Help Most Read Novel Cisplatin-Incorporated Polymeric Micelles Can Eradicate Solid Tumors in Mice Radiosensitivity of Thymidylate Synthase-deficient Human Tumor Cells Is Affected by Progression through the G1 Restriction Point into S-Phase: Implications for Fluoropyrimidine Radiosensitization Receptor Tyrosine Kinase Coactivation Networks in Cancer Metabolism and Cancer in La Jolla Neovascularization in Benign and Malignant Urinary Bladder Epithelial Proliferative Lesions of the Rat Observed in Situ by Scanning Electron Microscopy and Autoradiography » View all Most Read articles Cited ras Oncogenes in Human Cancer: A Review Mutations in the p53 Tumor Suppressor Gene: Clues to Cancer Etiology and Molecular Pathogenesis A National Cancer Institute Workshop on Microsatellite Instability for Cancer Detection and Familial Predisposition: Development of International Criteria for the Determination of Microsatellite Instability in Colorectal Cancer WAF1/CIP1 Is Induced in p53-mediated G1 Arrest and Apoptosis Specific Proteolytic Cleavage of Poly(ADP-ribose) Polymerase: An Early Marker of Chemotherapy-induced Apoptosis » View all Most Cited articles Home Current Issue Past Issues Subscriptions Alerts Feedback AACR Publications AACR Home Copyright © 2010 American Association for Cancer Research Online ISSN: 1538-7445 Print ISSN: 0008-5472
No comments:
Post a Comment